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KMID : 0613820060160061066
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Journal of Life Science
2006 Volume.16 No. 6 p.1066 ~ p.1070
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The Role of Receptor Activator of NF-кB Ligand in Smooth Muscle Cell Proliferation
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Kim Hyun-Joo
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Abstract
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Smooth muscle cell (SMC) proliferation is important in the pathogenesis of vascular proliferative disorders. Understanding of the molecular mechanism underlying SMC growth after arterial injury would have therapeutic implications. Here we report that receptor activator of NF-кB ligand (RANKL), a member of tumor necrosis factor (TNF) family, promotes the proliferation of SMC, leading to decreased expression of p21 and enhancement of SMC growth. ERK and p38 phosphorylation was enhanced after RANKL treatment in SMC. Inhibition of ERK/p38 MAPK activity by PD98059/SB203580 completely abolished RANKL-induced proliferation of SMC, indicating ERK and p38 MAPK are essential for RANKL-induced SMC proliferation. Taken together, our findings demonstrate that RANK-RANKL-ERK/p38 pathway is important for proliferation of SMC and that these molecules may be the new therapeutic targets for the prevention of vascular diseases.
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KEYWORD
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RANKL, SMC, proliferation, ERK, p38
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